Pharmacokinetic exercises In a 70kg test subject an oral 80mg dose of verapamil was administered. However because of extensive biotransformation during the first pass through portal circulation, the bioavailability was only 25%. Calculate the amount of the dose of the drug reaching the systemic circulation. A. Bioavailability is 25% = x 80 = 20 mg = 20 mg reaches systemic circulation A new antibiotic is being tested in clinical trials. The following pharmacokinetic parameters have been previously determined. Volume of distribution (vd) = 5L Half-life: 3Hours. Plasma concentration=0.1mg/ml. Calculate the elimination constant Calculate the loading dose. Elimination constant is given by the formula K e Loading dose is given by the formula L D = V d C P = 5L 0.1mg/ml = 5000ml X 0.1mg/ ml ...
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