1. Imipenem + cilastatin Imipenem : It is a beta lactams antibiotic. It binds to bacterial penicillin-binding proteins and interferes with bacterial cell wall integrity and synthesis. It is a bactericidal agent with wider antibacterial spectrum whose range of activity includes gram positive and gram negative aerobes and anaerobes (enterobacteriaceae, pseudomonas, Listeria, bacteroides fragilis, clostridium difficile). It is resistant to most beta lactamases, inhibits penicillinase producing staph aureusand some MRSA. Limiting feature of imipenem is – it is hydrolysed by the enzyme dehydropeptidase I located in the brush border of renal tubular cells. Cilastatin: It is a reversible inhibitor of dehydropeptidase I and thereby protects imipenem from degradation. It has similar pharmacokinetics as imipenem. It has half life of 1 hour. Dose: 0.5g IV 6hrly ` Maximum dose: 4g/day Uses Treatment of severe and complicated skin and skin structure infections, bone and joint infections, lower
Never too late to learn