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ANEUPLOIDY

ANEUPLOIDY

  Aneuploidy involves the loss or gain of one or more chromosomes.
 Loss of a single chromosome is called monosomy.
 Gain of one or two chromosomes is called trisomy, tetrasomy respectively.
 Depending on the type of chromosome involved it is classified as

 Autosomal monosomy- loss of one autosome, but the conception is not viable.
o Sex chromosomal monosomy- loss of one sex chromosome. Eg- Turner syndrome (45,X)
o Autosomal trisomy- gain of one autosome. Eg- Down syndrome (47,XX+21; 47,XY+21)
o Sex chromosomal trisomy- gain of one sex chromosome. Eg- Klinefelter syndrome
(47,XXY)
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