Karyotype- 47,XX+21; 47,XY+21, numerical chromosomal abnormality
Delayed developmental milestones
Mental retardation
Hypotonia
Brachycephaly
Open mouth & protruding tongue
Upward slant of palpebral fissures
Inner epicanthic folds
Small nose with flat nasal bridge
Small ears
Short neck
Simian crease in palm
Delayed developmental milestones
Mental retardation
Hypotonia
Brachycephaly
Open mouth & protruding tongue
Upward slant of palpebral fissures
Inner epicanthic folds
Small nose with flat nasal bridge
Small ears
Short neck
Simian crease in palm
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